Unexpected Balance

SERNIVO Spray is a prescription medicine that creates a balance of:

high penetration

low systemic absorption

Sernivo Mechanism of Balance

When SERNIVO is applied, it targets the different layers of the skin where
it can be most effective with low absorption into the bloodstream.a

aOf several prototype formulations tested in vitro, SERNIVO provided
the best balance of high penetration/permeation and low absorption.

Experience
elegance
redefined

SERNIVO improved skin hydration, and was shown to have moisturizing properties.
SERNIVO is made with patients in mind, providing:

  • a non-greasy treatment option
  • a versatile spray applicator
  • easy application on
    hard-to-reach areas
powerful results

In 2 clinical studies, SERNIVO effectively reduced the symptoms of mild-to-moderate
plaque psoriasis, such as itching, flaking, redness, size, and appearance.

Proven Treatment Successa,b,c

Progress as participants achieve clear or almost clear skina

11%

Day 8

11% of SERNIVO patients had achieved treatment success (compared with 4% for vehicle; p=0.010)a

20.3%

Day 15

20.3% of SERNIVO patients had achieved treatment success (compared with 5% for vehicle; p<0.001)a

38.7%

Day 29

38.7% of SERNIVO patients had achieved treatment success (compared with 12.6% for vehicle; p<0.001)a

Nearly 75% of all plaques on elbows and knees were clear or almost clear of redness
and scaling
after 29 days of treatment.

aTreatment success was defined as an Investigator's Global Assessment (IGA) of 0 or 1 (clear or almost clear) and at least a 2-grade reduction from baseline.
bPatients in clinical studies were adults (18 years and older) and had plaque psoriasis on 10% to 20% of their body surface area (BSA).
cPlease use as directed by your physician.

With proven tolerability
SERNIVO is
approved for up to
4 weeks
of use

In clinical studies, SERNIVO was well-tolerated by patients. In fact, during 28 days of treatment with SERNIVO, few patients experienced side effects.

The most common side effects reported during treatment with SERNIVO were:

  • pruritus (itching)
  • burning and/or stinging
  • pain
  • atrophy (skin thinning)

Side effects occurred in 6% of patients or less.

Ask your doctor if SERNIVO Spray may be right for you.
How to use SERNIVO SPRAY

STEP 1
SHAKE THE BOTTLE

Remove the cap from the pump top.

STEP 2
PUSH THE PUMP

Hold the bottle upright. Point the opening of the pump top toward the affected area. To spray, push down on the pump top.

NOTE: At first use, you may need to press the pump once or twice before SERNIVO can be sprayed.

STEP 3
RUB INTO SKIN

Spray only enough SERNIVO to cover the affected area. Gently rub SERNIVO into skin. Replace the cap.

Download Instructions